Gradient Hydrogels for Optimizing Niche Cues to Enhance Cell-Based Cartilage Regeneration.

ABSTRACT: Hydrogels have been widely used for cell delivery to enhance cell-based therapies for cartilage tissue regeneration. To better support cartilage deposition, it is imperative to determine hydrogel formulation with physical and biochemical cues that are optimized for different cell populations. Previous attempts to identify optimized hydrogels rely mostly on testing hydrogel formulations with discrete properties, which are time-consuming and require large amounts of cells and materials. Gradient hydrogels encompass a range of continuous changes in niche properties, therefore offering a promising solution for screening a wide range of cell-niche interactions using less materials and time. However, harnessing gradient hydrogels to assess how matrix stiffness modulates cartilage formation by di

SUBMITTER: Liu E 

PROVIDER: S-EPMC8336280 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature