Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells.

ABSTRACT: The sense of taste is mediated by taste buds on the tongue, which are composed of rapidly renewing taste receptor cells (TRCs). This continual turnover is powered by local progenitor cells and renders taste function prone to disruption by a multitude of medical treatments, which in turn severely impacts the quality of life. Thus, studying this process in the context of drug treatment is vital to understanding if and how taste progenitor function and TRC production are affected. Given the ethical concerns and limited availability of human taste tissue, mouse models, which have a taste system similar to humans, are commonly used. Compared to in vivo methods, which are time-consuming, expensive, and not amenable to high throughput studies, murine lingual organoids can enable experiments to be

SUBMITTER: Shechtman LA 

PROVIDER: S-EPMC8336305 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature