Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis.

ABSTRACT:

Background

Tumor microenvironment (TME) is associated with tumor progression and prognosis. Previous studies provided tools to estimate immune and stromal cell infiltration in TME. However, there is still a lack of single index to reflect both immune and stromal status associated with prognosis and immunotherapy responses.

Methods

A novel immune and stromal scoring system named ISTMEscore was developed. A total of 15 datasets were used to train and validate this system, containing 2965 samples from lung adenocarcinoma, skin cutaneous melanoma and head and neck squamous cell carcinoma.

Results

The patients with high immune and low stromal scores (HL) were associated with low ratio of T cell co-inhibitory/stimulatory molecules and low levels of angiogenesis markers, whi

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC8336334 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature