Regional effect on the molecular clock rate of protein evolution in Eutherian and Metatherian genomes.

ABSTRACT:

Background

Different types of proteins diverge at vastly different rates. Moreover, the same type of protein has been observed to evolve with different rates in different phylogenetic lineages. In the present study we measured the rates of protein evolution in Eutheria (placental mammals) and Metatheria (marsupials) on a genome-wide basis and we propose that the gene position in the genome landscape has an important influence on the rate of protein divergence.

Results

We analyzed a protein-encoding gene set (n = 15,727) common to 16 mammals (12 Eutheria and 4 Metatheria). Using sliding windows that averaged regional effects of protein divergence we constructed landscapes in which strong and lineage-specific regional effects were seen on the molecular clock rate of protein di

SUBMITTER: Huttener R 

PROVIDER: S-EPMC8336415 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature