The utility of second single antigen bead assay: Clearing the water or stirring up mud?

ABSTRACT: Though solid-phase single antigen bead (SAB) testing has provided major advances to the HLA community and organ allocation, it has not been without limitations. In particular, false-positive reactions lead to interpretative challenges and the potential to preclude a transplant if the corresponding antigens are deemed unacceptable. Two different vendor platforms are commercially available for SAB testing, one more recent than the other. The aim herein was to assess the benefit of using the newer SAB platform in situations where the primary platform yielded suspicious (specifically, false positive) reactions. Therefore, 42 serum samples with commonly encountered false-positive patterns observed in our laboratory were tested with the newer platform. Cases were classified as resolved, equivale

SUBMITTER: Sullivan HC 

PROVIDER: S-EPMC8336427 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature