Build a better bootstrap and the RAWR shall beat a random path to your door: phylogenetic support estimation revisited.

ABSTRACT:

Motivation

The standard bootstrap method is used throughout science and engineering to perform general-purpose non-parametric resampling and re-estimation. Among the most widely cited and widely used such applications is the phylogenetic bootstrap method, which Felsenstein proposed in 1985 as a means to place statistical confidence intervals on an estimated phylogeny (or estimate 'phylogenetic support'). A key simplifying assumption of the bootstrap method is that input data are independent and identically distributed (i.i.d.). However, the i.i.d. assumption is an over-simplification for biomolecular sequence analysis, as Felsenstein noted.

Results

In this study, we introduce a new sequence-aware non-parametric resampling technique, which we refer to as RAWR ('RAndom Walk Re

SUBMITTER: Wang W 

PROVIDER: S-EPMC8336443 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature