Heterogeneity in insulin-stimulated glucose uptake among different muscle groups in healthy lean people and people with obesity.

ABSTRACT:

Aims/hypothesis

It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body, insulin resistance in people with obesity. The goal of the study was to evaluate the relationships among muscle fibre type composition, perfusion and insulin-stimulated glucose uptake rates in healthy, lean people and people with obesity.

Methods

We measured insulin-stimulated whole-body glucose disposal and glucose uptake and perfusion rates in five major muscle groups (erector spinae, obliques, rectus abdominis, hamstrings, quadriceps) in 15 healthy lean people and 37 people with obesity by using the hyperinsuli

SUBMITTER: Koh HE 

PROVIDER: S-EPMC8336476 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature