Ontology highlight
ABSTRACT:
SUBMITTER: Kleczewska N
PROVIDER: S-EPMC8336483 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Kleczewska Natalia N Sikorski Pawel J PJ Warminska Zofia Z Markiewicz Lukasz L Kasprzyk Renata R Baran Natalia N Kwapiszewska Karina K Karpinska Aneta A Michalski Jaroslaw J Holyst Robert R Kowalska Joanna J Jemielity Jacek J
Chemical science 20210629 30
Targeting cap-dependent translation initiation is one of the experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5',5'-triphosphates cap analogs are potent antagonists of eukaryotic translation initiation factor 4E (eIF4E) <i>in vitro</i> and could counteract elevated levels of eIF4E in cancer cells; however, transformation of these compounds into therapeutic agents remains challenging - they do not easily penetrate into cells and are ...[more]