Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

ABSTRACT: As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi-material inkjet-based 3D printing can meet this demand by combining functional materials, voxelated manufacturing, and algorithmic design. In this paper composite structures designed with both controlled deformation and reduced biofilm formation are manufactured using two formulations that are deposited selectively and separately. The bacterial biofilm coverage of the resulting composites is reduced by up to 75% compared to commonly used silicone rubbers, without the need for incorporating bioactives. Meanwhile, the composites can be tuned to meet user defined me

SUBMITTER: He Y 

PROVIDER: S-EPMC8336490 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature