Dataset Information

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

ABSTRACT: As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi-material inkjet-based 3D printing can meet this demand by combining functional materials, voxelated manufacturing, and algorithmic design. In this paper composite structures designed with both controlled deformation and reduced biofilm formation are manufactured using two formulations that are deposited selectively and separately. The bacterial biofilm coverage of the resulting composites is reduced by up to 75% compared to commonly used silicone rubbers, without the need for incorporating bioactives. Meanwhile, the composites can be tuned to meet user defined mechanical performance with ±10% deviation. Device manufacture is coupled to finite element modelling and a genetic algorithm that takes the user-specified mechanical deformation and computes the distribution of materials needed to meet this under given load constraints through a generative design process. Manufactured products are assessed against the mechanical and bacterial cell-instructive specifications and illustrate how multifunctional personalization can be achieved using generative design driven multi-material inkjet based 3D printing.

SUBMITTER: He Y

PROVIDER: S-EPMC8336490 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

He Yinfeng Y Abdi Meisam M Trindade Gustavo F GF Begines Belén B Dubern Jean-Frédéric JF Prina Elisabetta E Hook Andrew L AL Choong Gabriel Y H GYH Ledesma Javier J Tuck Christopher J CJ Rose Felicity R A J FRAJ Hague Richard J M RJM Roberts Clive J CJ De Focatiis Davide S A DSA Ashcroft Ian A IA Williams Paul P Irvine Derek J DJ Alexander Morgan R MR Wildman Ricky D RD

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210529 15

As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi-material inkjet-based 3D printing can meet this demand by combining functional materials, voxelated manufacturing, and algorithmic design. In this paper composite structures designed with both controlled deformation and reduced biofilm formation are manufactured using ...[more]

PMID: 34050725

Similar Datasets

Project description:Inertial microfluidics has been broadly investigated, resulting in the development of various applications, mainly for particle or cell separation. Lateral migrations of these particles within a microchannel strictly depend on the channel design and its cross-section. Nonetheless, the fabrication of these microchannels is a continuous challenging issue for the microfluidic community, where the most studied channel cross-sections are limited to only rectangular and more recently trapezoidal microchannels. As a result, a huge amount of potential remains intact for other geometries with cross-sections difficult to fabricate with standard microfabrication techniques. In this study, by leveraging on benefits of additive manufacturing, we have proposed a new method for the fabrication of inertial microfluidic devices. In our proposed workflow, parts are first printed via a high-resolution DLP/SLA 3D printer and then bonded to a transparent PMMA sheet using a double-coated pressure-sensitive adhesive tape. Using this method, we have fabricated and tested a plethora of existing inertial microfluidic devices, whether in a single or multiplexed manner, such as straight, spiral, serpentine, curvilinear, and contraction-expansion arrays. Our characterizations using both particles and cells revealed that the produced chips could withstand a pressure up to 150?psi with minimum interference of the tape to the total functionality of the device and viability of cells. As a showcase of the versatility of our method, we have proposed a new spiral microchannel with right-angled triangular cross-section which is technically impossible to fabricate using the standard lithography. We are of the opinion that the method proposed in this study will open the door for more complex geometries with the bespoke passive internal flow. Furthermore, the proposed fabrication workflow can be adopted at the production level, enabling large-scale manufacturing of inertial microfluidic devices.

Dataset Information

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

Publications

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets