Therapies with diverse mechanisms of action kill cells by a similar exponential process in advanced cancers.

ABSTRACT: Successful cancer treatments are generally defined as those that decrease tumor quantity. In many cases, this decrease occurs exponentially, with deviations from a strict exponential being attributed to a growing fraction of drug-resistant cells. Deviations from an exponential decrease in tumor quantity can also be expected if drugs have a nonuniform spatial distribution inside the tumor, for example, because of interstitial pressure inside the tumor. Here, we examine theoretically different models of cell killing and analyze data from clinical trials based on these models. We show that the best description of clinical outcomes is by first-order kinetics with exponential decrease of tumor quantity. We analyzed the total tumor quantity in a diverse group of clinical trials with various canc

SUBMITTER: Blagoev KB 

PROVIDER: S-EPMC8336537 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature