A Versatile and Robust Platform for the Scalable Manufacture of Biomimetic Nanovaccines.

ABSTRACT: Biomimetic strategies are useful for designing potent vaccines. Decorating a nanoparticulate adjuvant with cell membrane fragments as the antigen-presenting source exemplifies, such as a promising strategy. For translation, a standardizable, consistent, and scalable approach for coating nanoadjuvant with the cell membrane is important. Here a turbulent mixing and self-assembly method called flash nanocomplexation (FNC) for producing cell membrane-coated nanovaccines in a scalable manner is demonstrated. The broad applicability of this FNC technique compared with bulk-sonication by using ten different core materials and multiple cell membrane types is shown. FNC-produced biomimetic nanoparticles have promising colloidal stability and narrow particle polydispersity, indicating an equal or mo

SUBMITTER: Hu H 

PROVIDER: S-EPMC8336609 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature