Automated PET-RAFT Polymerization Towards Pharmaceutical Amorphous Solid Dispersion Development.

ABSTRACT: In pharmaceutical oral drug delivery development, about 90% of drugs in the pipeline have poor aqueous solubility leading to severe challenges with oral bioavailability and translation to effective and safe drug products. Amorphous solid dispersions (ASDs) have been utilized to enhance the oral bioavailability of poorly soluble active pharmaceutical ingredients (APIs). However, a limited selection of regulatory-approved polymer excipients exists for the development and further understanding of tailor-made ASDs. Thus, a significant need exists to better understand how polymers can be designed to interact with specific API moieties. Here, we demonstrate how an automated combinatorial library approach can be applied to the synthesis and screening of polymer excipients for the model drug probu

SUBMITTER: Upadhya R 

PROVIDER: S-EPMC8336633 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature