Exploring regulation and function of dopamine D3 receptors in alcohol use disorder. A PET [¹¹C]-(+)-PHNO study.

ABSTRACT: Preclinical studies support an important role of dopamine D3 receptors (DRD3s) in alcohol use disorder (AUD). In animals, voluntary alcohol consumption increases DRD3 expression, and pharmacological blockade of DRD3s attenuates alcohol self-administration and reinstatement of alcohol seeking. However, these findings have yet to be translated in humans. This study used positron emission tomography (PET) and [¹¹C]-(+)-PHNO to compare receptor levels in several dopamine D2 receptor (DRD2) and DRD3 regions of interest between AUD subjects in early abstinence (n = 17; 6.59 ± 4.14 days of abstinence) and healthy controls (n = 18). We recruited non-treatment seeking subjects meeting DSM-5 criteria for AUD. We examined the relationship between DRD2/3 levels and both alcohol craving and

SUBMITTER: Chukwueke CC 

PROVIDER: S-EPMC8336665 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature