MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes expressing an αβ T cell antigen receptor that recognises the MHC-related 1 molecule. MAIT cells are altered in children at risk for and with type 1 diabetes, and mouse model studies have shown MAIT cell involvement in type 1 diabetes development. Since several studies support heterogeneity in type 1 diabetes physiopathology according to the age of individuals, we investigated whether MAIT cells were altered in adults with type 1 diabetes.

Methods

MAIT cell frequency, phenotype and function were analysed by flow cytometry, using fresh peripheral blood from 21 adults with recent-onset type 1 diabetes (2-14 days after disease onset) and 47 adults with long-term disease (>2 years after diag

SUBMITTER: Nel I 

PROVIDER: S-EPMC8336671 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature