Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study.

ABSTRACT:

Background

African ancestry individuals with comparable overall anthropometric measures to Europeans have lower abdominal adiposity. To explore the genetic underpinning of different adiposity patterns, we investigated whether genetic risk scores for well-studied adiposity phenotypes like body mass index (BMI) and waist circumference (WC) also predict other, less commonly measured adiposity measures in 2420 African American individuals from the Jackson Heart Study.

Methods

Polygenic risk scores (PRS) were calculated using GWAS-significant variants extracted from published studies mostly representing European ancestry populations for BMI, waist-hip ratio (WHR) adjusted for BMI (WHRBMIadj), waist circumference adjusted for BMI (WCBMIadj), and body fat percentage (BF%). Associat

SUBMITTER: Anwar MY 

PROVIDER: S-EPMC8336790 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature