Four Prognosis-Associated lncRNAs Serve as Biomarkers in Ovarian Cancer.

ABSTRACT: Long non-coding RNAs (lncRNAs) play crucial roles in ovarian cancer (OC) development. However, prognosis-associated lncRNAs (PALs) for OC have not been completely elucidated. Our study aimed to identify the PAL signature of OC. A total of 663 differentially expressed lncRNAs were identified in the databases. According to the weighted gene coexpression analysis, the highly correlated genes were clustered into seven modules related to the clinical phenotype of OC. A total of 25 lncRNAs that were significantly related to overall survival were screened based on univariate Cox regression analysis. The prognostic risk model constructed contained seven PALs based on the parameter λ_min, which could stratify OC patients into two risk groups. The results showed that the risk groups had di

SUBMITTER: Zheng J 

PROVIDER: S-EPMC8336869 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature