Ontology highlight
ABSTRACT:
SUBMITTER: Grunberg N
PROVIDER: S-EPMC8337092 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Grunberg Nil N Pevsner-Fischer Meirav M Goshen-Lago Tal T Diment Judith J Stein Yaniv Y Lavon Hagar H Mayer Shimrit S Levi-Galibov Oshrat O Friedman Gil G Ofir-Birin Yifat Y Syu Li-Jyun LJ Migliore Cristina C Shimoni Eyal E Stemmer Salomon M SM Brenner Baruch B Dlugosz Andrzej A AA Lyden David D Regev-Rudzki Neta N Ben-Aharon Irit I Scherz-Shouval Ruth R
Cancer research 20210205 7
Gastric cancer is the third most lethal cancer worldwide, and evaluation of the genomic status of gastric cancer cells has not translated into effective prognostic or therapeutic strategies. We therefore hypothesize that outcomes may depend on the tumor microenvironment (TME), in particular, cancer-associated fibroblasts (CAF). However, very little is known about the role of CAFs in gastric cancer. To address this, we mapped the transcriptional landscape of human gastric cancer stroma by microdi ...[more]