Structural Pharmacology of TRP Channels.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC8338738 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Structural Pharmacology of TRP Channels.
Zhao Yaxian Y McVeigh Bridget M BM Moiseenkova-Bell Vera Y VY
Journal of molecular biology 20210305 17
Transient receptor potential (TRP) ion channels are a super-family of ion channels that mediate transmembrane cation flux with polymodal activation, ranging from chemical to physical stimuli. Furthermore, due to their ubiquitous expression and role in human diseases, they serve as potential pharmacological targets. Advances in cryo-EM TRP channel structural biology has revealed general, as well as diverse, architectural elements and regulatory sites among TRP channel subfamilies. Here, we review ...[more]
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