Characterization of the multidrug efflux transporter styMdtM from Salmonella enterica serovar Typhi.

ABSTRACT: Salmonellae are foodborne pathogens and the major cause of gastroenteritis in humans. Salmonellae express multidrug efflux transporters that play a key role in their drug resistance, which is becoming an increasing problem for therapeutic intervention. Despite their biomedical importance, the mechanisms underlying substrate transport by multidrug efflux transporters remain poorly understood. Here, we describe the first characterization of a multidrug transporter belonging to the major facilitator superfamily from the genus Salmonella. We show that several clinical Salmonella Typhi (S. Typhi) isolates constitutively express the styMdtM (STY4874) gene, which encodes a known multidrug-resistance (MDR) transporter. Guided by the structure of the Escherichia coli (E. coli) homolog, we studied t

SUBMITTER: Shaheen A 

PROVIDER: S-EPMC8338744 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature