Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo.

ABSTRACT:

Purpose

Delivery of radiation at ultrahigh dose rates (UHDRs), known as FLASH, has recently been shown to preferentially spare normal tissues from radiation damage compared with tumor tissues. However, the underlying mechanism of this phenomenon remains unknown, with one of the most widely considered hypotheses being that the effect is related to substantial oxygen depletion upon FLASH, thereby altering the radiochemical damage during irradiation, leading to different radiation responses of normal and tumor cells. Testing of this hypothesis would be advanced by direct measurement of tissue oxygen in vivo during and after FLASH irradiation.

Methods and materials

Oxygen measurements were performed in vitro and in vivo using the phosphorescence quenching method and a water-solu

SUBMITTER: Cao X 

PROVIDER: S-EPMC8338745 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature