Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.

ABSTRACT:

Introduction

Trauma is the leading cause of death among young people. These patients have a high incidence of kidney injury, which independently increases the risk of mortality. As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury.

Methods

We analyzed data from two separate experiments where swine were subjected to lethal insults.  Model 1: hemorrhage (50% blood volume hemorrhage followed by 72-h damage control resuscitation). Model 2: polytrauma (traumatic brain injury, 40% blood volume hemorrhage, femur fracture, rectus crush and grade V liver laceration). Animals were resuscitated with normal saline (NS) +/- VPA 150 mg/kg after a 1-h shock phase

SUBMITTER: Biesterveld BE 

PROVIDER: S-EPMC8338771 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature