Fetal Growth Trajectories Among Small for Gestational Age Babies and Child Neurodevelopment.

ABSTRACT:

Background

Being born small for gestational age (SGA, <10th percentile) is a risk factor for worse neurodevelopmental outcomes. However, this group is a heterogeneous mix of healthy and growth-restricted babies, and not all will experience poor outcomes. We sought to determine whether fetal growth trajectories can distinguish who will have the worst neurodevelopmental outcomes in childhood among babies born SGA.

Methods

The present analysis was conducted in Generation R, a population-based cohort in Rotterdam, the Netherlands (N = 5,487). Using group-based trajectory modeling, we identified fetal growth trajectories for weight among babies born SGA. These were based on standard deviation scores of ultrasound measures from mid-pregnancy and late pregnancy in combination with

SUBMITTER: Ferguson KK 

PROVIDER: S-EPMC8338787 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature