Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia.

ABSTRACT:

Background

Prenatal immune development may play an important role in the etiology of childhood acute lymphoblastic leukemia (ALL).

Methods

Seven cytokines, IL1β, IL4, IL6, IL8, GM-CSF, TNFα, and VEGF, were analyzed in blood spots collected at birth from 1,020 ALL cases and 1,003 controls participating in the California Childhood Leukemia Study. ORs and 95% confidence intervals (95% CI) associated with an interquartile range increment in cytokine levels were calculated using logistic regression, adjusting for sociodemographic and birth characteristics.

Results

We found that patients with ALL were born with higher levels of a group of correlated cytokines than controls [IL1β: OR of 1.18 (95% confidence interval [CI], 1.03-1.35); IL8: 1.19 (1.03-1.38); TNFα: 1.15 (1.01-1

SUBMITTER: Whitehead TP 

PROVIDER: S-EPMC8338848 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature