The Association between Polluted Neighborhoods and TP53-Mutated Non-Small Cell Lung Cancer.

ABSTRACT:

Background

Poor patients often reside in neighborhoods of lower socioeconomic status (SES) with high levels of airborne pollutants. They also have higher mortality from non-small cell lung cancer (NSCLC) than those living in wealthier communities. We investigated whether living in polluted neighborhoods is associated with somatic mutations linked with lower survival rates, i.e., TP53 mutations.

Methods

In a retrospective cohort of 478 patients with NSCLC treated at a comprehensive cancer center between 2015 and 2018, we used logistic regression to assess associations between individual demographic and clinical characteristics, including somatic TP53 mutation status and environmental risk factors of annual average particulate matter (PM_2.5) levels, an

SUBMITTER: Erhunmwunsee L 

PROVIDER: S-EPMC8338883 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature