A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome.

ABSTRACT: Recent technological advances in mass spectrometry have enabled us to screen biological samples for a very broad spectrum of chemical compounds allowing us to more comprehensively characterize the human exposome in critical periods of development. The goal of this study was three-fold: (1) to analyze 590 matched maternal and cord blood samples (total 295 pairs) using non-targeted analysis (NTA); (2) to examine the differences in chemical abundance between maternal and cord blood samples; and (3) to examine the associations between exogenous chemicals and endogenous metabolites. We analyzed all samples with high-resolution mass spectrometry using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) in both positive and negative electrospray ionization modes (ESI+ a

SUBMITTER: Panagopoulos Abrahamsson D 

PROVIDER: S-EPMC8338910 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature