Deciphering the biology of KIR2DL3⁺ T lymphocytes that are associated to relapse in haploidentical HSCT.

ABSTRACT: KIR are mainly expressed on NK cells and to a lesser extent on T lymphocytes. Although the KIR NK cell repertoire was well explored in haploidentical Hematopoietic Stem Cell Transplantation (HSCT), KIR T cell compartment remains to be investigated in this context. In this study, the investigation of NK receptors on T lymphocytes during immune reconstitution after T-cell-replete haploidentical HSCT with Post-Transplant Cyclophosphamide (PTCy) has shown a significant increase of KIR2DL2/3⁺ T cell frequency at day 25. This was especially observed at day 30 in recipients who relapsed. IL-15 but not IL-12 increased in vitro KIR⁺ T cell expansion suggesting that the raised IL-15 serum concentration observed after PTCy in haploidentical HSCT might increase KIR⁺ T

SUBMITTER: David G 

PROVIDER: S-EPMC8338934 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature