Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report.

ABSTRACT: Side effects to antidepressant medications are common and can impact the prognosis of successful treatment outcome in people with major depressive disorder (MDD). However, few studies have investigated the severity of side effects over the course of treatment and their association with treatment outcome. Here we assessed the severity of side effects and the impact of treatment type and anxiety symptoms over the course of treatment, as well as whether side effects were associated with treatment outcome. Participants were N = 1008 adults with a current diagnosis of single-episode or recurrent, nonpsychotic MDD. Participants were randomised to receive escitalopram, sertraline, or venlafaxine-extended release with equal probability and reassessed at 8 weeks regarding Hamilton Rating Scale Depr

SUBMITTER: Braund TA 

PROVIDER: S-EPMC8338944 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature