Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro.

ABSTRACT: Metastatic disease remains the leading cause of death in cancer and understanding the mechanisms involved in tumor progression continues to be challenging. This work investigates the role of manganese in tumor progression in an in vivo model of tumor growth. Our data revealed that manganese accumulates within primary tumors and secondary organs as manganese-rich niches. Consequences of such phenomenon were investigated, and we verified that short-term changes in manganese alter cell surface molecules syndecan-1 and β1-integrin, enhance collective cell migration and invasive behavior. Long-term increased levels of manganese do not affect cell growth and viability but enhance cell migration. We also observed that manganese is secreted from tumor cells in extracellular vesicles, rather than i

SUBMITTER: Stelling MP 

PROVIDER: S-EPMC8338990 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature