Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer.

ABSTRACT: Primary cancer cells exert unique capacity to disseminate and nestle in distant organs. Once seeded in secondary sites, cancer cells may enter a dormant state, becoming resistant to current treatment approaches, and they remain silent until they reactivate and cause overt metastases. To illuminate the complex mechanisms of cancer dormancy, 10 transcriptomic datasets from the literature enabling 21 dormancy-cancer comparisons were mapped on protein-protein interaction networks and gene-regulatory networks to extract subnetworks that are enriched in significantly deregulated genes. The genes appearing in the subnetworks and significantly upregulated in dormancy with respect to proliferative state were scored and filtered across all comparisons, leading to a dormancy-interaction network for t

SUBMITTER: Uzuner D 

PROVIDER: S-EPMC8339123 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature