Elucidating the complementarity of resting-state networks derived from dynamic [¹⁸F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI.

ABSTRACT: Functional connectivity (FC) and resting-state network (RSN) analyses using functional magnetic resonance imaging (fMRI) have evolved into a growing field of research and have provided useful biomarkers for the assessment of brain function in neurological disorders. However, the underlying mechanisms of the blood oxygen level-dependant (BOLD) signal are not fully resolved due to its inherent complexity. In contrast, [¹⁸F]fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG-PET) has been shown to provide a more direct measure of local synaptic activity and may have additional value for the readout and interpretation of brain connectivity. We performed an RSN analysis from simultaneously acquired PET/fMRI data on a single-subject level to directly compare fMRI and

SUBMITTER: Ionescu TM 

PROVIDER: S-EPMC8339191 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature