Novel Compound Q-1 Alleviates Type II Collagen-Induced Arthritis in Rats through the NF-κB Pathway.

ABSTRACT:

Background

Q-1 is a novel compound extracted from the Miao medicine Tiekuaizi. Although Q-1 is known to be a coumarin derivative, its structure has not been deposited in the ACX library. Our previous study showed that Q-1 inhibits the activity of inflammatory cells. This study explores the efficacy of Q-1 in regulating rheumatoid arthritis (RA). The findings show that Q-1 acts through the NF-κB signaling pathway.

Methods

The effects of Q-1 were explored using a bovine type II collagen-induced arthritis (CIA) rat model. The CIA rats were intragastrically administered with high (30 mg·kg^-1) or low (15 mg·kg^-1) doses of Q-1. The control group was administered with an equal volume of drinking water, while the positive control group was administered w

SUBMITTER: Xu T 

PROVIDER: S-EPMC8339345 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature