SARS-CoV-2 viral load at presentation to hospital is independently associated with the risk of death.

ABSTRACT: Objectives Previous studies have suggested that SARS-CoV-2 viral load, measured on upper respiratory tract samples at presentation to hospital using PCR Cycle threshold (Ct) value, has prognostic utility. However, these studies have not comprehensively adjusted for factors known to be intimately related to viral load. We aimed to evaluate the association between Ct value at admission and patient outcome whilst adjusting carefully for covariates. Methods We evaluated the association between Ct value at presentation and the outcomes of ICU admission and death, in patients hospitalised during the first wave of the pandemic in Southampton, UK. We adjusted for covariates including age, duration of illness and antibody sero-status, measured by neutralisation assay. Results 185 patients were anal

SUBMITTER: Tanner AR 

PROVIDER: S-EPMC8339449 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature