Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.

ABSTRACT: Aurora kinase A (AURKA) is a conserved kinase that plays crucial roles in numerous cellular processes. Although AURKA overexpression is frequent in human cancers, its pleiotropic functions and multifaceted regulation present challenges in its therapeutic targeting. Key to overcoming these challenges is to identify and characterize the full range of AURKA interactors, which are often weak and transient. Previous proteomic studies were limited in monitoring dynamic and non-mitotic AURKA interactions. Here, we generate the proximity interactome of AURKA in asynchronous cells, which consists of 440 proteins involving multiple biological processes and cellular compartments. Importantly, AURKA has extensive proximate and physical interactions to centriolar satellites, key regulators of the prima

SUBMITTER: Arslanhan MD 

PROVIDER: S-EPMC8339716 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature