Fractional analysis of bronchoalveolar lavage in systemic sclerosis-associated interstitial lung disease.

ABSTRACT:

Background

The utility of bronchoalveolar lavage (BAL) in the evaluation of systemic sclerosis-associated interstitial lung disease (SSc-ILD) remains controversial. Fractional analysis of BAL (FBAL) is a technique that can analyze small airways and alveolar compartments separately and has proven informative in other ILDs. The aim of this study was to explore FBAL characteristics across the spectrum of SSc-ILD severity.

Methods

We retrospectively reviewed patients with SSc-ILD who underwent bronchoscopy with FBAL using three 50 mL aliquots of saline solution. These aliquots were analyzed separately for differential cell composition (FBAL-1, -2, and -3). We compared the FBAL cell composition to the progression of ILD and end-stages of ILD using Cox proportional hazards models.

SUBMITTER: Kase K 

PROVIDER: S-EPMC8339759 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature