A simple assessment of lung nodule location for reduction in unnecessary invasive procedures.

ABSTRACT:

Background

CT screening for lung cancer results in a significant mortality reduction but is complicated by invasive procedures performed for evaluation of the many detected benign nodules. The purpose of this study was to evaluate measures of nodule location within the lung as predictors of malignancy.

Methods

We analyzed images and data from 3,483 participants in the National Lung Screening Trial (NLST). All nodules (4-20 mm) were characterized by 3D geospatial location using a Cartesian coordinate system and evaluated in logistic regression analysis. Model development and probability cutpoint selection was performed in the NLST testing set. The Geospatial test was then validated in the NLST testing set, and subsequently replicated in a new cohort of 147 participants from T

SUBMITTER: Kinsey CM 

PROVIDER: S-EPMC8339782 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature