SMOX expression predicts the prognosis of non-small cell lung cancer.

ABSTRACT:

Background

The development of non-small cell lung cancer (NSCLC) is very rapid, and the effect of its treatment is often closely related to the diagnosis time of the disease. Therefore, simple and convenient tumor biomarkers are helpful for the timely diagnosis and prevention of NSCLC.

Methods

Through univariate and multivariate Cox regression analyses, SMOX was determined as an independent prognostic factor of GSE42127, GSE41271, GSE68465, and TCGA datasets. Furthermore, western blot, reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemical analysis were performed to confirm the predictive efficiency of SMOX expression in NSCLC.

Results

Patients were divided into high and low expression groups according to the median value of SMOX expression,

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8339854 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature