Prognostic and immune implications of a novel ferroptosis-related ten-gene signature in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer has been the focus of attention for many researchers in recent years due to its leading contribution to cancer-related death worldwide, with lung adenocarcinoma (LUAD) being the most common histological type. Ferroptosis, a novel iron-dependent form of regulated cell death, can be induced by sorafenib. Emerging evidence shows that triggering ferroptosis has potential as a cancer therapy. This work aimed to build a ferroptosis-related gene signature for predicting the outcome of LUAD.

Methods

The TCGA-LUAD dataset was set as the training cohort, and the GSE72094 and GSE68465 datasets were set as the validation cohorts. Sixty-two ferroptosis-related genes were retrieved from the literature. A univariate Cox regression model was constructed for the traini

SUBMITTER: Ma C 

PROVIDER: S-EPMC8339871 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature