Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function.

ABSTRACT: Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the characterization of enzymes that catalyze the addition and removal this modification. In this review we summarize what has been learned about lysine fatty acylation in the approximately 30 years since its initial discovery. We report on what is known about the enzymes that regulate lysine fatty acylation and their physiological functions, including tumorigenesis and bacterial pathogenesis. We also cover the effect of lysine fatty acylation on reported substrates. Generally, lysine fatty acylation increases the affinity of proteins for specific cellular

SUBMITTER: Komaniecki G 

PROVIDER: S-EPMC8339906 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature