The DmsABC Sulfoxide Reductase Supports Virulence in Non-typeable Haemophilus influenzae.

ABSTRACT: Although molybdenum-containing enzymes are well-established as having a key role in bacterial respiration, it is increasingly recognized that some may also support bacterial virulence. Here, we show that DmsABC, a putative dimethylsulfoxide (DMSO) reductase, is required for fitness of the respiratory pathogen Haemophilus influenzae (Hi) in different models of infection. Expression of the dmsABC operon increased with decreasing oxygen availability, but despite this, a Hi2019^{Δd msA} strain did not show any defects in anaerobic growth on chemically defined medium (CDM), and viability was also unaffected. Although Hi2019^{Δd msA} exhibited increased biofilm formation in vitro and greater re

SUBMITTER: Dhouib R 

PROVIDER: S-EPMC8340005 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature