Blood DNA Methylation and Incident Coronary Heart Disease: Evidence From the Strong Heart Study.

ABSTRACT:

Importance

American Indian communities experience a high burden of coronary heart disease (CHD). Strategies are needed to identify individuals at risk and implement preventive interventions.

Objective

To investigate the association of blood DNA methylation (DNAm) with incident CHD using a large number of methylation sites (cytosine-phosphate-guanine [CpG]) in a single model.

Design, setting, and participants

This prospective study, including a discovery cohort (the Strong Heart Study [SHS]) and 4 additional cohorts (the Women's Health Initiative [WHI], the Framingham Heart Study [FHS], the Atherosclerosis Risk in Communities Study ([ARIC]-Black, and ARIC-White), evaluated 12 American Indian communities in 4 US states; African American women, Hispanic women, and White

SUBMITTER: Navas-Acien A 

PROVIDER: S-EPMC8340006 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature