Incorporating oral PrEP into standard prevention services for South African women: a nested interrupted time-series study.

ABSTRACT:

Background

As oral pre-exposure prophylaxis (PrEP) becomes the standard of prevention globally, its potential effect on HIV incidence in clinical trials of new prevention interventions is unknown, particularly for trials among women. In a trial measuring HIV incidence in African women, oral PrEP was incorporated into the standard of prevention in the trial's last year. We assessed the effect of on-site access to PrEP on HIV incidence in this natural experiment.

Methods

We did a nested interrupted time-series study using data from the ECHO trial. At 12 sites in four countries (Eswatini, Kenya, South Africa, and Zambia), women (aged 16-35 years) were randomly assigned to receive one of three contraceptives between Dec 14, 2015, and Sept 12, 2017, and followed up quarterly for

SUBMITTER: Donnell D 

PROVIDER: S-EPMC8340029 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature