Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity.

ABSTRACT:

Background

Staphylococcus aureus is a common human pathogen capable of causing diverse illnesses with possible recurrent infections. Although recent studies have highlighted the role of cellular immunity in recurrent infections, the mechanism by which S. aureus evades host responses remains largely unexplored.

Methods

This study utilizes in vitro and in vivo infection experiments to investigate difference of pro-inflammatory responses and subsequent adaptive immune responses between adsA mutant and WT S. aureus strain infection.

Findings

We demonstrated that adenosine synthase A (AdsA), a potent S. aureus virulence factor, can alter Th17 responses by interfering with NLRP3 inflammasome-mediated IL-1β production. Specifically, S. aureus virulence factor AdsA dampens Th

SUBMITTER: Deng J 

PROVIDER: S-EPMC8340124 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature