Integrative omics analysis reveals effective stratification and potential prognosis markers of pan-gastrointestinal cancers.

ABSTRACT: Gastrointestinal (GI) tract cancers are the most common malignant cancers with high mortality rate. Pan-cancer multi-omics data fusion provides a powerful strategy to examine commonalities and differences among various cancer types and benefits for the identification of pan-cancer drug targets. Herein, we conducted an integrative omics analysis on The Cancer Genome Atlas pan-GI samples including six carcinomas and stratified into 9 clusters, i.e. 5 single-type-dominant clusters and 4 mixed clusters, the clustering reveals the molecular features of different subtypes, other than the organ and cell-of-origin classifications. Especially the mixed clusters revealed the homogeneity of pan-GI cancers. We demonstrated that the prognosis differences among pan-GI subtypes based on multi-omics integ

SUBMITTER: Jiangzhou H 

PROVIDER: S-EPMC8340129 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature