Exposure to methylphenidate during peri-adolescence decouples the prefrontal cortex: a multimodal MRI study.

ABSTRACT: This study was designed to assess the effects of daily psychostimulant exposure during juvenility and peri-adolescence on brain morphology and functional connectivity using multimodal magnetic resonance imaging. We hypothesized that long-term exposure to methylphenidate would enhance connectivity with the prefrontal cortex. Male rats were given daily injections of either methylphenidate (n=10), dextroamphetamine (n=10) or saline vehicle (n=10) from postnatal day 21 to 42. They were imaged between postnatal day 43 and 48. Voxel-based morphometry, diffusion weighted imaging, and resting state functional connectivity were used to quantify brain structure and function. Images from each modality were registered and analyzed, using a 3D MRI rat atlas providing site-specific data over 171 differe

SUBMITTER: Demaree JL 

PROVIDER: S-EPMC8340152 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature