In silico identification of promising inhibitor against RNA-dependent RNA polymerase target of SARS-CoV-2.

ABSTRACT: The severe acute respiratory syndrome is a viral respiratory disease recognised as COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Formerly, no precise remedies are available, and many studies regarding COVID-19 prevention and treatment are under development. Several targets for the design of drugs are identified, and studies are in headway to explore the potential target. RNA-dependent RNA polymerase (RdRp) protein identified as a promising target against SARS-CoV-2 infection for the drug design due to its significant role in viral replication. The present study focuses on identifying the binding effect of previously known RdRp inhibitors with RdRp of SARS-CoV-2 using molecular docking and molecular dynamics simulation approaches. Molecular docking and bi

SUBMITTER: Singh P 

PROVIDER: S-EPMC8340315 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature