Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA methylation (DNAm) is a plausible mechanism underlying these shifts, considering that DNAm profiles differ across tissues and cell types, and DNAm may play a role in cell-type differentiation. Previous work investigating the relationship between DNAm and fibrosis in NAFLD has been limited by sample size and the number of CpG sites interrogated.

Results

Here, we performed an epigenome-wide analysis using Infinium MethylationEPIC array data from 325 individuals with NAFLD, including 119 with severe fibrosis and 206 with no histological evidence of fibrosis. After

SUBMITTER: Johnson ND 

PROVIDER: S-EPMC8340447 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature