Hemodynamic, renal and hormonal effects of lung protective ventilation during robot-assisted radical prostatectomy, analysis of secondary outcomes from a randomized controlled trial.

ABSTRACT:

Background

Lung protective ventilation with low tidal volume (TV) and increased positive end-expiratory pressure (PEEP) can have unfavorable effects on the cardiovascular system. We aimed to investigate whether lung protective ventilation has adverse impact on hemodynamic, renal and hormonal variables.

Methods

In this randomized, single-blinded, placebo-controlled study, 24 patients scheduled for robot-assisted radical prostatectomy were included. Patients were equally randomized to receive either ventilation with a TV of 6 ml/IBW and PEEP of 10 cm H₂O (LTV-h.PEEP) or ventilation with a TV of 10 ml/IBW and PEEP of 4 cm H₂O (HTV-l.PEEP). Before, during and after surgery, hemodynamic variables were measured, and blood and urine samples were collected. Blo

SUBMITTER: Hoyer S 

PROVIDER: S-EPMC8340542 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature