Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia.

ABSTRACT:

Background

Sensorineural hearing loss in beta-thalassemia is common and it is generally associated with iron chelation therapy. However, data are scarce, especially on adult populations, and a possible involvement of the central auditory areas has not been investigated yet. We performed a multicenter cross-sectional audiological and single-center 3Tesla brain perfusion MRI study enrolling 77 transfusion-dependent/non transfusion-dependent adult patients and 56 healthy controls. Pure tone audiometry, demographics, clinical/laboratory and cognitive functioning data were recorded.

Results

Half of patients (52%) presented with high-frequency hearing deficit, with overt hypoacusia (Pure Tone Average (PTA) > 25 dB) in 35%, irrespective of iron chelation or clinical phenotype. Bila

SUBMITTER: Manara R 

PROVIDER: S-EPMC8340544 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature