Bioreactor control systems in the biopharmaceutical industry: a critical perspective.

ABSTRACT: Industrial-scale bioprocessing underpins much of the production of pharmaceuticals, nutraceuticals, food, and beverage processing industries of the modern world. The profitability of these processes increasingly leverages the economies of scale and scope that are critically dependent on the product yields, titers, and productivity. Most of the processes are controlled using classical control approaches and represent over 90% of the industrial controls used in bioprocessing industries. However, with the advances in the production processes, especially in the biopharmaceutical and nutraceutical industries, monitoring and control of bioprocesses such as fermentations with GMO organisms, and downstream processing has become increasingly complex and the inadequacies of the classical and some of

SUBMITTER: Mitra S 

PROVIDER: S-EPMC8340809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature