Dietary magnesium deficiency induces the expression of neuroinflammation-related genes in mouse brain.

ABSTRACT:

Aims

Dietary Mg²⁺ deficiency (MgD) impairs hippocampus-dependent memory in mice; however, the molecular mechanisms underlying MgD-induced memory impairments are unclear. Here, we investigated the molecular signatures in the hippocampus of MgD mice by analyzing the hippocampal transcriptome.

Methods

We performed RNA-sequencing of the hippocampal transcriptome of MgD mice. We used gene ontology analyses and quantitative real-time PCR to validate the RNA-sequencing results.

Results

mRNAs for neuroinflammation-related genes were upregulated in the hippocampus and cortex of MgD mice.

Conclusion

MgD induces neuroinflammation in the mouse brain, including the hippocampus and cortex. Our findings suggest that MgD-induced neuroinflammation triggers the impair

SUBMITTER: Tsuji R 

PROVIDER: S-EPMC8340841 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature